EFFECTS OF THEOPHYLLINE ON PNEUMOGRAM ABNORMALITIES IN INFANTS WITH VARYING PRESENTATIONS

Autor:	D. Vidyasagar, N Rusnak, E Beaty, Kristine McCulloch
Rok vydání:	1984
Předmět:	Bradycardia Pediatrics medicine.medical_specialty business.industry Apnea Sudden infant death syndrome Gastroenterology Asymptomatic Internal medicine Periodic breathing Pediatrics Perinatology and Child Health medicine Theophylline medicine.symptom business Full term infants medicine.drug
Zdroj:	Pediatric Research. 18:397A-397A
ISSN:	1530-0447 0031-3998
DOI:	10.1203/00006450-198404001-01827
Popis:	Pneumograms before and after theophylline (T) were obtained in 48 infants who comprised 5 groups: 1) asymptomatic low birthweight infants (A-LBW,n=8); 2)LBW infants with symptomatic apnea (S-LBW, n= 15); 3) infants with histories of "near-miss for sudden infant death syndrome (SIDS)" (S-NM,n=7); 4) full term infants with spells of apnea, bradycardia or cyanosis in the nursery (S-FT,n=12); 5) asymptomatic infants with a family history of SIDS (A=FH,n=6). Initial pneumograms showed one or more of the following during sleep: 1) prolonged (>15 sec.) apnea; 2) % periodic breathing (PB) high for age; 3) # episodes PB/100 min. high for age; 4) time spent in apnea ≥6 sec. (A6/D%) high for age. Post-T pneumograms were obtained after at least 48 hrs. of therapy (peak serum level x±SD= 10.0 ± 2.7 mcg/ml). Comparisons were made by t test, paired t test and Chi square. S-LBW had the most abnormal pre-T pneumograms with % PB and # PB/100 min. significantly higher than in S-NM and S-FT. Pneumograms improved in all patients after T with elimination of prolonged apnea in all but one (p
Databáze:	OpenAIRE
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