Commercial Scale Process of Galanthamine Hydrobromide Involving Luche Reduction: Galanthamine Process Involving Regioselective 1,2-Reduction of α,β-Unsaturated Ketone

Autor:	Koilpillai Joseph Prabahar, Anand Gopalkrishna Kamat, Ganala Naga Trinadhachari, Paul Douglas Sanasi, Korupolu Raghu Babu, Kukunuri Naga Venkata Satya Srinu, Vijay Kumar Handa
Rok vydání:	2013
Předmět:	Lanthanide Organic Chemistry Regioselectivity Chloride Sodium borohydride chemistry.chemical_compound Luche reduction chemistry Unsaturated ketone Yield (chemistry) medicine Organic chemistry Galanthamine Hydrobromide Physical and Theoretical Chemistry medicine.drug
Zdroj:	Organic Process Research & Development. 17:406-412
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op300337y
Popis:	Effect of lanthanide chloride in the Luche regioselective 1,2-reduction of 1-bromo-11-formyl-nornarwedine (5) was studied. Thus, 1-bromo-11-formyl-nornarwedine (5) is reduced with sodium borohydride in the presence of lanthanide chloride to yield 1-bromo-11-formyl-galanthamine isomers (6), which is a key intermediate for the commercial production of highly pure galanthamine hydrobromide (1), a modern drug against Alzheimer’s disease.
Databáze:	OpenAIRE
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