Diterpenoid Alkaloids as Antidotes to Aconitine-Type Neurotoxin Poisoning. Structure–Activity Relationship
| Autor: | F. M. Tursunkhodzhaeva, B. T. Salimov, F. N. Dzhakhangirov |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
biology
010405 organic chemistry medicine.medical_treatment Consolida Plant Science General Chemistry Pharmacology biology.organism_classification complex mixtures 01 natural sciences General Biochemistry Genetics and Molecular Biology 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Delphinium medicine Aconitine Structure–activity relationship heterocyclic compounds Batrachotoxin Antidote Veratridine Aconitum |
| Zdroj: | Chemistry of Natural Compounds. 52:849-852 |
| ISSN: | 1573-8388 0009-3130 |
| DOI: | 10.1007/s10600-016-1794-1 |
| Popis: | The in vivo antidote activity of 72 diterpenoid alkaloids isolated from plants of the genera Aconitum, Delphinium, and Consolida and their derivatives was tested against poisoning of mice by a lethal dose of aconitine. The structure–activity relationship was analyzed. The use of diterpenoid alkaloids as versatile antidotes against poisoning of animals and humans by aconitine-, veratridine-, and batrachotoxin-type neurotoxins was justified. |
| Databáze: | OpenAIRE |
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