| Autor: |
Eugenio Damasio, M. Truini, A. Isaza, Marco Risso, Elena Rossi, Cerri R, Salvatore Casciaro, M. Siccardi, Mauro Spriano, B Masoudi, Marco Gobbi, Marino Clavio, Sandro Nati |
| Rok vydání: |
2000 |
| Předmět: |
|
| Zdroj: |
European Journal of Haematology. 64:47-52 |
| ISSN: |
0902-4441 |
| Popis: |
Although in recent years the use of purine analogues has increased the percentage of long-term complete response the effect on overall survival of patients with hairy cell leukemia (HCL) is not yet clear. This study aimed to evaluate the long-term outcome (mean follow up of 92 months) of 64 patients receiving IFN as first-line therapy. IFN was well tolerated and effective. The overall response rate was 91% (PR 65%, CR 13%, GPR 13%). Forty-one patients (63%) received IFN 3 MU/ wk as maintenance therapy. The 10-yr projected survival rate of responding patients (CR and GPR 100%; PR 95%) and non-responders (SD, PD 80%) clearly shows that type of response does not affect survival. Patients receiving IFN maintenance had a statistically higher PFS than those who did not (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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