ChemInform Abstract: Design and Synthesis of a New Sialyl Lewis X Mimetic: How Selective Are the Selectin Receptors?

Autor:	Marc Vaillancourt, Yvan Guindon, Marc De Vleeschauwer, Denis Gravel, Nathalie Goudreau
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Sialyl-Lewis X Molecular model Chemistry Stereochemistry Ic50 values General Medicine Enantiomer Receptor Receptor binding specificity Selectin Biological evaluation
Zdroj:	ChemInform. 32
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200132099
Popis:	The present paper reports the molecular modeling-based design and synthesis of an optically pure noncarbohydrate mimetic of sialyl Lewis X to inhibit E-selectin. Biological evaluation of the designed substance as well as that of its enantiomer gave, contrary to expectations, comparable IC50 values. Results are discussed in terms of receptor binding specificity and the molecular modeling protocol used.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0849b66591f66b87b859dd5aff402af4 https://doi.org/10.1002/chin.200132099 Zobrazit plný text záznamu Plný text