Efficient Domino Synthesis of Pyrrole-Fused Isocoumarins with Microwave Heating

Autor: Cong-Shuai Wang, Yi-Jing Dang, Kai Liu, Xiao-Yan Meng, Shu-Jiang Tu, Fei Jiang, Bo Jiang, Fu-Jie Zhao, Mu-Yan Sun
Rok vydání: 2014
Předmět:
Zdroj: European Journal of Organic Chemistry. 2014:3690-3696
ISSN: 1434-193X
DOI: 10.1002/ejoc.201402164
Popis: A new three-component approach to polyfunctionalized isochromeno[4,3-b]pyrroles has been developed with excellent regioselectivity. During these domino reactions, two ring-opening and three cyclization reactions were readily achieved through carbon–carbon bond cleavage under transition-metal-free conditions. The advantages of atom and step economy, and scope make this reaction a powerful tool for assembling tri-heterocyclic scaffolds of general chemical and biomedical interest.
Databáze: OpenAIRE
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