Synthesis of arylpiperazines via palladium-catalyzed aromatic amination reaction with unprotected piperazines

Autor:	Aubry K. Miller, Flippin Lee Allen, Zhao Shu-Hai, Berger Jacob
Rok vydání:	1996
Předmět:	chemistry.chemical_compound chemistry Aryl Organic Chemistry Drug Discovery Organic chemistry Halide chemistry.chemical_element Biochemistry Amination Coupling reaction Catalysis Palladium
Zdroj:	Tetrahedron Letters. 37:4463-4466
ISSN:	0040-4039
DOI:	10.1016/0040-4039(96)00877-5
Popis:	A series of arylpiperazines were synthesized in moderate to good yields by palladium-catalyzed coupling reaction of aryl halides with unprotected piperazines. Very high regioselectivities were observed when using 2-methyl or 2,6-dimethylpiperazine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::08458fe2a35c548b2ea44ee1d47e2e95 https://doi.org/10.1016/0040-4039(96)00877-5 Zobrazit plný text záznamu Full Text from ScienceDirect