Effects of Early and Late Ischemic Preconditioning of the Brain on the Severity of Hippocampal Neuron Injury and the Degree of Neurological Deficit in Rats

Autor:	L. B. Mitrofanova, E. V. Shlyakhto, T. Yu. Vyboldina, Michael M. Galagudza, N. S. Shcherbak, E. R. Barantsevich, Nifontov Em
Rok vydání:	2014
Předmět:	medicine.medical_specialty business.industry General Neuroscience Ischemia Hippocampus Hippocampal formation medicine.disease Neuroprotection medicine.anatomical_structure Internal medicine medicine Cardiology Hippocampal neuron Ischemic preconditioning Neuron business Neurological deficit
Zdroj:	Neuroscience and Behavioral Physiology. 44:415-420
ISSN:	1573-899X 0097-0549
DOI:	10.1007/s11055-014-9927-0
Popis:	The aim of the present work was to investigate the neuroprotective effects of early and late ischemic preconditioning (IPreC) in the acute phase of ischemic brain damage in rats. Single 5-min ischemic episodes of early IPreC were found not to produce significant neuroprotective effects as compared with controls, while three 5-min episodes of early IPreC led to significant increases in neurological deficit and increases in the level of neuron injury in hippocampal field CA1. Conversely, late IPreC, consisting of a single 5-min episode 24 h before modeling test ischemia, produced a significant neuroprotective effect, with decreased neurological deficit and retention of hippocampal field CA1 neuron viability.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::083f38d560c5190c0e9026ef7564ea71 https://doi.org/10.1007/s11055-014-9927-0 Zobrazit plný text záznamu Full text from SpringerLink