Efeito do hexametônio sobre a contratilidade de músculo liso de cobaios provocada pelo extrato aquoso do fungo Ramaria Flavo Brunnescens

Autor:	Ana Maria Chagas, José Antonio Aguilar Vaca, Zuleica Tabarelli, Ruben Boelter, Rejane Flores, Lisandre Kipper
Rok vydání:	1986
Předmět:	biology medicine.medical_treatment Ileum Stimulation Ramaria Smooth muscle contraction Ramaria flava Pharmacology biology.organism_classification medicine.anatomical_structure Toxicity medicine General Earth and Planetary Sciences Ingestion Antidote General Environmental Science
Zdroj:	Ciência e Natura. 8:67
ISSN:	2179-460X 0100-8307
Popis:	Animals poisoning by ingestion of Ramaria flava brunnescens fungus found in Eucalipto groves is common in Southern Brazil. This poisoning does not have an effective antidote yet and it is common to avoid the toxicity by removing the animals from these fields or by using atropin when fungus intoxication signals appear. Present work was reallized to elucidate the manner and place of action of this fungus aqueous extract on isolated guinea pig ileum. For this purpose, we used Magnus Bath and strain transducer to Physiograph connect. Experiences were realized with 18 ileum tested with 10 mcg Nicotine. 24.600 mcg Ramaria flavo brunnescens fungus' aqueous extract and 30 mcg Hexametonium. Those concentrations were choosen from pilot experiences. The results showed that uses of this fungus extract provokes smooth muscle contraction similar to that of nicotin, the difference between both occurs due to Hexametone blockade impossibility. This fact suggests that the death mechanism of animals that eat this fungus is not due to ganglionar stimulation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::08388e4db5805251794c6d766e9f3b77 https://doi.org/10.5902/2179460x25441 Zobrazit plný text záznamu