Effect of Dietary Phosphorus Levels on Porcine Renal 25-Hydroxyvitamin D-1α- and 24R-Hydroxylase Activities and Plasma 1,25-Dihydroxyvitamin D3 Concentration1

Autor:	George W. Engstrom, E. Travis Littledike, Timothy A. Reinhardt, Ronald L. Horst
Rok vydání:	1985
Předmět:	medicine.medical_specialty Chemistry Alpha (ethology) General Medicine D-1 Vitamin D+Metabolites Endocrinology Internal medicine Genetics medicine Alkaline phosphatase Animal Science and Zoology Food Science Dietary Phosphorus
Zdroj:	Journal of Animal Science. 60:1005-1011
ISSN:	1525-3163 0021-8812
DOI:	10.2527/jas1985.6041005x
Popis:	Results of studies on the effect of dietary P deprivation on pig renal 1 alpha- and 24-hydroxylase activities and on concentrations of plasma alkaline phosphatase, Ca, P and vitamin D metabolites are presented. Renal 1 alpha-hydroxylase activity was increased six- to eightfold and plasma 1,25-dihydroxyvitamin D3 concentration increased two- to threefold in pigs fed a low P diet (.085% P) compared with pigs fed a control diet (.6% P). In contrast, renal 24-hydroxylase activity and plasma 25-hydroxyvitamin D concentration did not differ between diet groups. Plasma alkaline phosphatase activity was two to four times higher in pigs fed the low P diet compared with pigs fed the control diet. The rate of gain by pigs fed the low P diet was less than pigs fed the control diet. The low P diet was associated with a prolonged elevation of renal 1 alpha-hydroxylase activity in spite of the presence of a pronounced hypercalcemia.
Databáze:	OpenAIRE
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