Pathohistological assessment of preoperative treatment combined with intraarterial chemotherapy and radiotherapy in squamous cell carcinomas of the head and neck. Comparison of effects between cisplatin and carboplatin
Autor: | Yoshitaka Igakura, Ryosuke Shiba, Mitsuhiro Komura, Ryoji Arima, Masato Hamada, Kentaro Higashi, Sumio Sakoda |
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Rok vydání: | 1996 |
Předmět: |
Cisplatin
medicine.medical_specialty Chemotherapy business.industry medicine.medical_treatment Head and neck cancer Histology medicine.disease Tegafur Gastroenterology Carboplatin Surgery Radiation therapy chemistry.chemical_compound chemistry Internal medicine medicine Mucositis business medicine.drug |
Zdroj: | Japanese Journal of Oral & Maxillofacial Surgery. 42:22-28 |
ISSN: | 2186-1579 0021-5163 |
Popis: | The effects of two different neo-adjuvant chemo- and radio-therapies against squamous cell carcinomas of the head and neck were compared histologically.Group A consisted of 15 patients who received intra-arterial cisplatin (20 mg/m 2) on day 1 and 8, and intrarectal tegafur (1500 mg/day) from day 1 through 14, and irradiation of 2 Gy from day 1 through 5 and from day 8 throughGroup B consisted of 14 patients, who received intra-arterial carboplatin (100 mg/m 2) on day 1 and 8, and intrarectal tegafur (1500 mg /day) from day 1 through 14, and irradiation of 2 Gy from day 1 through 5 and from day 8 through 12.There was no difference between the groups in sex, age, T- and Stage-classification, and tumor cell differentiation.Therapeutic effects were evaluated according to Oboshi's classification on the basis of resected tumor tissues. A grade of II B or more was judged as respondent, and a grade of less than Grade II A as nonrespondent. Seven out of 15 patients (46.7%) in group A and 8 out of 14 patients (57.1%) in Group B were judged as respondent. There was no significant difference in the respondent rate between the two groups. Mucositis occurred frequently, but surgery was not delayed in any patient. |
Databáze: | OpenAIRE |
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