Three-component reductive alkylation of 2-hydroxy-1,4-naphthoquinones with lactols

Autor:	Liangfeng Fu, Gordon W. Gribble, Timothy M. Abbot, Evans O. Onyango, Eliana E. Kim, Jennifer R. Pace
Rok vydání:	2016
Předmět:	010405 organic chemistry Component (thermodynamics) Lactol Organic Chemistry Alkylation 010402 general chemistry 01 natural sciences Biochemistry Tautomer Naphthoquinone 0104 chemical sciences chemistry.chemical_compound chemistry Drug Discovery Organic chemistry
Zdroj:	Tetrahedron Letters. 57:864-867
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2016.01.036
Popis:	Lactols II , obtained by DIBAL reduction of their corresponding lactones I , in equilibrium with their hydroxyaldehyde tautomers III were used in a three-component reductive alkylation with 2-hydroxy-1,4-naphthoquinone to give a series of 3-alkylated 2-hydroxy-1,4-naphthoquinone derivatives IV .
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0820bf5278379533a4c0ac94f4b76b6a https://doi.org/10.1016/j.tetlet.2016.01.036 Zobrazit plný text záznamu Full Text from ScienceDirect