Gastroprotective effect of zosterin, a pectin from seagrass ZOSTERA MARINA L
| Autor: | Marina N. Sgrebneva, Piotr A. Tiupeleev, Eleonora I. Khasina |
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| Rok vydání: | 2004 |
| Předmět: |
Diminution
food.ingredient Pectin biology Glycogen business.industry Stomach Emotional stress Pharmacology biology.organism_classification chemistry.chemical_compound medicine.anatomical_structure food Complementary and alternative medicine Biochemistry chemistry Zosteraceae Gastric mucosa medicine Zostera marina business |
| Zdroj: | Oriental Pharmacy and Experimental Medicine. 4:253-260 |
| ISSN: | 1598-2386 |
| DOI: | 10.3742/opem.2004.4.4.253 |
| Popis: | Zosterin is a pectin from a seagrasses of the family Zosteraceae. Zosterin was given to rats intragastrically once 1h before the emotional stress or injection of indomethacin, or administration of 2, 4-D solution daily for seven days at dose of 100 mg/kg. The data obtained demonstrate that zosterin enhances resistance of the stomach tissue to various ulcerogenic factors (emotional stress, indomethacin, pesticide 2, 4-D). It was shown to possess a gastroprotective effect, which is accompanied by diminution of the number and sizes of destructive regions in the gastric mucosa during the ulcer affection, as well as reduction of ATP and glycogen deficit, decrease of lactate excess, and normalization of the energy balance in the gastric mucosa. According to its antiulcer effect, zosterin may be recommended for application in prevention and treatment of stomach diseases together with the basic therapy. |
| Databáze: | OpenAIRE |
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