Effect ofl-lysine-α-oxidase on the synthesis of proteins associated with autoimmune pathologies in HIV infection
| Autor: | V. V. Zverev, T. T. Berezov, I. Z. Zaitsev, S. B. Alekseev |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
chemistry.chemical_classification
Oxidase test Lysine Human immunodeficiency virus (HIV) General Medicine Biology medicine.disease_cause Molecular biology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Enzyme Histone chemistry Antigen biology.protein Protein biosynthesis medicine DNA |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 123:30-32 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf02764371 |
| Popis: | In HIV-infected MT-4 cells,l-lysine-α-oxidase, an inhibitor of HIV reproduction, selectively inhibits the synthesis of histone proteins, including 18K antigen (H2B histone). This protein is the target for autoimmune suppression of helper T cells. The enzyme has a low effect on the synthesis of other proteins and DNA. In addition to 18K antigen,l-lysine-α-oxidase suppresses the synthesis of high-molecular-weight proteins (270, 220, 140, 100, 75, 70, and 60 kD). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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