Gene therapy for cardiovascular diseases

Autor:	Robert I Grove, Margaret M Snowden
Rok vydání:	1998
Předmět:	Pharmacology Vascular disease business.industry Genetic enhancement Late stage Gene transfer General Medicine medicine.disease Bioinformatics Restenosis Drug Discovery medicine business Gene
Zdroj:	Expert Opinion on Therapeutic Patents. 8:509-520
ISSN:	1744-7674 1354-3776
DOI:	10.1517/13543776.8.5.509
Popis:	The advent of gene therapy techniques has made it possible to intervene in cardiovascular diseases by transferring an appropriate therapeutic gene to the relevant cells in humans. A number of preclinical efforts have begun to culminate in clinical studies for life threatening conditions like hypercholesterolaemia and ischaemic vascular disease. Other cardiovascular indications are under investigation, with late stage preclinical studies focusing on restenosis, transplant atherosclerosis and rejection, and various lipoprotein abnormalities. Several recent reviews have outlined the issues surrounding gene therapy in general [1,2]. This review will discuss gene transfer approaches designed specifically to treat diseases of the cardiovascular system, and relevant patents and patent applications.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0817a058d72b7f7580b40054607f9679 https://doi.org/10.1517/13543776.8.5.509 Zobrazit plný text záznamu