Sequential hydroarylation/Prins cyclization: an efficient strategy for the synthesis of angularly fused tetrahydro-2H-pyrano[3,4-c]quinolines

Autor:	M. Rajashekhar Reddy, G. Ravi Kumar, Suresh Yarlagadda, B. Sridhar, J. S. Yadav, C. Ravikumar Reddy, B. V. Subba Reddy
Rok vydání:	2016
Předmět:	Tandem 010405 organic chemistry Chemistry General Chemical Engineering High selectivity Quinoline General Chemistry Prins reaction 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound Organic chemistry
Zdroj:	RSC Advances. 6:113390-113394
ISSN:	2046-2069
DOI:	10.1039/c6ra21375h
Popis:	Various aldehydes undergo a smooth cascade cyclization with N-(5-hydroxypent-2-yn-1-yl)-4-methyl-N-phenylbenzenesulfonamide in the presence of 10 mol% Ph3PAuCl/AgSbF6/In(OTf)3 to furnish the corresponding tetrahydro-2H-pyrano[3,4-c]quinoline derivatives in good yields with high selectivity. This is the first report on the synthesis of tetrahydro-2H-pyrano[3,4-c]quinolines through a tandem hydroarylation/Prins cyclization process.
Databáze:	OpenAIRE
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