Brief Report: Genetic Variation of the α1 -Antitrypsin Gene Is Associated With Increased Autoantibody Production in Rheumatoid Arthritis
| Autor: | Geraldine M. McCarthy, Douglas J. Veale, Paul O'Connell, Dermot Kenny, Eimear Dunne, Danielle M Dunlea, Emer P. Reeves, David J. L. Hunt, Carl Orr, Tomás P. Carroll, Ursula Fearon, Laura T. Fee, Noel G. McElvaney, Cormac McCarthy |
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| Rok vydání: | 2017 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine Immunofixation Anti-nuclear antibody Immunology Population 03 medical and health sciences 0302 clinical medicine Rheumatology Immunology and Allergy Medicine Rheumatoid factor Allele skin and connective tissue diseases education 030203 arthritis & rheumatology education.field_of_study biology business.industry Antibody titer Autoantibody medicine.disease 030104 developmental biology Rheumatoid arthritis biology.protein business |
| Zdroj: | Arthritis & Rheumatology. 69:1576-1579 |
| ISSN: | 2326-5191 |
| DOI: | 10.1002/art.40127 |
| Popis: | Objective To examine the prevalence of α1-antitrypsin deficiency (AATD) in rheumatoid arthritis (RA), and to determine whether AATD is associated with higher levels of rheumatoid factor (RF), antinuclear antibodies (ANAs), and anti–citrullinated peptide autoantibodies (ACPAs). Methods RF, ANAs, and ACPAs were measured by standard immunoturbidimetry, immunofluorescence assay, and enzyme-linked immunosorbent assay, respectively. Characterization of AAT phenotypes was performed by isoelectric focusing and immunofixation. The chi-square test with Yates' correction and the Mann-Whitney U test were used to assess the prevalence of alleles associated with AATD in RA and to compare mean antibody titers, respectively. Results Of 246 patients with RA, 24 who were heterozygous for AATD were identified, with no statistically significant difference in the prevalence of AATD between RA patients and the general population (P = 0.39). A positive association between heterozygosity for AATD and the production of ACPAs was observed (P |
| Databáze: | OpenAIRE |
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