Increase in visceral and subcutaneous abdominal fat in men with prostate cancer treated with androgen deprivation therapy

Autor:	Emily J Gianatti, Emma J. Hamilton, Mathis Grossmann, Jeffrey D Zajac, John M. Wentworth, Damien M Bolton, D. Lim-Joon, Boyd Josef Gimnicher Strauss
Rok vydání:	2011
Předmět:	medicine.medical_specialty Intra-Abdominal Fat business.industry Endocrinology Diabetes and Metabolism Adipose tissue Type 2 diabetes medicine.disease Androgen deprivation therapy Prostate cancer Endocrinology Insulin resistance Internal medicine medicine Metabolic syndrome business Testosterone
Zdroj:	Clinical Endocrinology. 74:377-383
ISSN:	0300-0664
DOI:	10.1111/j.1365-2265.2010.03942.x
Popis:	Summary Objective Androgen deprivation therapy (ADT) for prostate cancer is associated with increases in fat mass and risk of type 2 diabetes; however, the relationship between sex steroid deficiency and abdominal fat distribution remains controversial. Design We conducted a 12-month prospective observational study at a tertiary referral centre. Patients and measurements We investigated changes in abdominal fat distribution and insulin resistance in 26 men (70·6 ± 6·8 years) with nonmetastatic prostate cancer during the first year of ADT. Results Twelve months of ADT increased visceral abdominal fat area by 22% (from 160·8 ± 61·7 to 195·9 ± 69·7 cm2; P
Databáze:	OpenAIRE
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