| Autor: |
Hanne F. Harbo, Steffan D. Bos, Ingvild Sørum Leikfoss, Valeria Vitelli, Frode S. Berven, Chiara Cappelletti, Oda Glomstad Kråbøl, Tone Berge, Einar August Høgestøl, Olav Mjaavatten, Ina Skaara Brorson, Anna Eriksson |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
SSRN Electronic Journal. |
| ISSN: |
1556-5068 |
| DOI: |
10.2139/ssrn.3859665 |
| Popis: |
Multiple sclerosis (MS) is an autoimmune, neurodegenerative disorder with a strong genetic component that acts in a complex interaction with environmental factors for disease development. CD4+ T cells are pivotal players in MS pathogenesis, where peripherally activated T cells migrate to the central nervous system leading to demyelination and axonal degeneration. In the current study, we evaluated dysregulation of CD4+ T cell activation at the protein level using electrospray liquid chromatography-tandem mass spectrometry to get insights into immune-cell processes in MS. Our study highlights the importance of CD4+ T cell activation for MS, as proteins that change in abundance upon T cell activation are enriched for proteins encoded by MS susceptibility genes. Our results provide evidence for proteomic disturbances in T cell activation in MS, and pinpoint to dysregulation of the Nur77 pathway, a biological pathway known to limit aberrant effector T cell responses. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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