Chlorine-35 nuclear magnetic resonance study of zinc-nucleotide triphosphate complexes
| Autor: | Raymond L. Ward, James A. Happe |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
chemistry.chemical_classification
Cytidine triphosphate Inorganic chemistry General Engineering Isotopes of chlorine chemistry.chemical_element Zinc Metal Crystallography chemistry.chemical_compound chemistry visual_art visual_art.visual_art_medium Proton NMR Nucleotide Physical and Theoretical Chemistry Adenosine triphosphate Uridine triphosphate |
| Zdroj: | The Journal of Physical Chemistry. 83:3457-3462 |
| ISSN: | 1541-5740 0022-3654 |
| DOI: | 10.1021/j100489a029 |
| Popis: | The interaction of Zn(II) with nucleotide triphosphates has been studied by /sup 35/Cl NMR and by /sup 1/H NMR. In 0.5 M NaCl solutions, enhanced /sup 35/Cl relaxation is produced by the metal ion in a Zn(II)-nucleotide triphosphate complex, Zn(NTP). In equimolar metal-ligand solutions, the adenosine triphosphate complex, Zn(ATP)/sup 2 -/, produces about twice as much /sup 35/Cl relaxation as do the inosine triphoshate or uridine triphosphate complexes, Zn(ITP)/sup 2 -/ and Zn(UTP)/sup 2 -/. /sup 35/Cl relaxation by the cytidine triphosphate complex, Zn(CTP)/sup 2 -/, is intermediate. In each case, the enhanced /sup 35/Cl relaxation found, relative to the Zn/sup 2 +/(aq) value, is removed by interaction with excess nucleotide. In the presence of excess Zn(II) ions, purine nucleotides form complexes which have high /sup 35/Cl molar relaxivity metal ion environments. These observations are discussed in terms of possible structures which could lead to such relaxation environments. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|