Development of an Optimized Process for the Preparation of 1-Benzylazetidin-3-ol: An Industrially Important Intermediate for Substituted Azetidine

Autor:	E. Mahesh Reddy, Ch. Kameswararao, G. Madhusudhan, D. Udaykiran, V. V. R. M. Krishna Reddy, U. S. Chintamani
Rok vydání:	2011
Předmět:	chemistry.chemical_compound Benzylamine chemistry Hydrochloride Scientific method Organic Chemistry Azetidine Organic chemistry Physical and Theoretical Chemistry
Zdroj:	Organic Process Research & Development. 15:462-466
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op100247m
Popis:	A thoroughly optimized and robust process for the synthesis of 1-benzylazetidin-3-ol has been emphasized. 1-Benzylazetidin-3-ol has been utilized as a starting material in the commercial synthesis of azetidin-3-ol hydrochloride. Synthesis of azetidin-3-ol hydrochloride involves the usage of very low cost and commercially available starting material (benzylamine) and with reduced formation of di(3-chloro-2-hydroxypropyl) benzylamine significantly resulting in an economical process that allows the effective production of 1-benzyl azetidin-3-ol as well as azetidin-3-ol hydrochloride.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::07e5675a2e39d0d69a4c89b446107193 https://doi.org/10.1021/op100247m Zobrazit plný text záznamu