Preparation of copper(II) oxide bound on polystyrene beads and its application in the aryl aminations: synthesis of Imatinib

Autor:	Sunwoo Lee, Manian Rajesh Kumar, Dajung Hyun, Hyun Min Jung, Yumi Heo
Rok vydání:	2012
Předmět:	Aryl Organic Chemistry chemistry.chemical_element Biochemistry Copper Coupling reaction Copper(II) oxide Catalysis chemistry.chemical_compound chemistry Bromide Yield (chemistry) Drug Discovery Polymer chemistry Polystyrene
Zdroj:	Tetrahedron Letters. 53:6657-6661
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2012.09.097
Popis:	CuO nanoflakes bound on polystyrene beads (PS-CuO) were prepared through the oxidation of copper(I) bromide in a suspension of polystyrene. The use of PS-CuO as a catalyst in the presence of KO t Bu in the coupling reactions of aryl bromides and amines afforded the coupled products with a yield range of 15–89%. This catalytic system also afforded the key fragment in good yield for the synthesis of Imatinib (Gleevec).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::07e17f08b36c9ac6952cb7bb44a902d0 https://doi.org/10.1016/j.tetlet.2012.09.097 Zobrazit plný text záznamu Full Text from ScienceDirect