Aspartic and glutamic acids polymers: preparation and applications in medicinal chemistry and pharmaceutics
| Autor: | Elena Efremenko, Olga Maslova, Olga Senko |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Green chemistry biology Homoserine 02 engineering and technology General Chemistry Polymer 010402 general chemistry 021001 nanoscience & nanotechnology biology.organism_classification Antimicrobial 01 natural sciences Medicinal chemistry 0104 chemical sciences Amino acid chemistry.chemical_compound Monomer chemistry Pharmaceutics 0210 nano-technology Bacteria |
| Zdroj: | Russian Chemical Bulletin. 67:614-623 |
| ISSN: | 1573-9171 1066-5285 |
| Popis: | The methods of the fabrication of polymers based on aspartic and glutamic acids as monomers are reviewed. The methods are perspective from the viewpoint of green chemistry and economics. Actual tendencies existing in the application of the polymers in medicinal chemistry and pharmaceutics are also considered. The results of using mentioned polymers of amino acids to obtain stable nanosized enzymatic complex drugs, based on organophosphate hydrolase and possessing both antibacterial and antineurotoxic action are presented. The drugs are effective destructors of N-acyl homoserine lactones, playing the role of signaling molecules for the quorum response of gram-negative bacteria. These enzymatic-polymer complexes in combination with well-known antibiotics reduce antimicrobial doses inhibiting growth of the pathogens. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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