Synthesis and Antimicrobial and Antifungal Activity of Carbamate-Functionized Spiro Compounds

Autor:	L. T. Sukhenko, O. V. Degtyarev, A. V. Velikorodov, V. A. Ionova
Rok vydání:	2013
Předmět:	Pharmacology Carbamate biology Stereochemistry Chemistry medicine.medical_treatment Micrococcus Trichophyton rubrum Pyrazole biology.organism_classification Condensation reaction Antimicrobial chemistry.chemical_compound Drug Discovery medicine Microsporum canis Candida albicans
Zdroj:	Pharmaceutical Chemistry Journal. 46:715-719
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-013-0876-7
Popis:	A series of carbamate-functionalized spiro compounds were synthesized by [3+2]-cycloaddition and condensation reactions based on methyl {4(3)-[2-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)acetyl]phenyl}carbamates. The antimicrobial activity with respect to E. coli, S. aureus 209, and Micrococcus and antifungal activity with respect to Microsporum canis, Trichophyton rubrum, and Candida albicans were investigated. The most active of the synthesized compounds were spiro compounds with isoxazoline and pyrazole fragments.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::07d75732a3f70971d448521f8b08a094 https://doi.org/10.1007/s11094-013-0876-7 Zobrazit plný text záznamu Plný text ve formátu PDF