Epileptiform activity in traumatic brain injury predicts post-traumatic epilepsy
| Autor: | Sahar F. Zafar, M. Brandon Westover, Emily J. Boyle, Jennifer A. Kim, Alexander C. Wu, Kevin J. Staley, Sydney S. Cash, Andrew J. Cole |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.diagnostic_test Traumatic brain injury business.industry Retrospective cohort study Odds ratio Electroencephalography medicine.disease 03 medical and health sciences Epilepsy 030104 developmental biology 0302 clinical medicine nervous system Neurology Anesthesia medicine Neurology (clinical) Young adult Post-traumatic epilepsy Risk factor business 030217 neurology & neurosurgery |
| Zdroj: | Annals of Neurology. 83:858-862 |
| ISSN: | 0364-5134 |
| DOI: | 10.1002/ana.25211 |
| Popis: | We hypothesize that epileptiform abnormalities (EAs) in the electroencephalogram (EEG) during the acute period following traumatic brain injury (TBI) independently predict first-year post-traumatic epilepsy (PTE1 ). We analyze PTE1 risk factors in two cohorts matched for TBI severity and age (n = 50). EAs independently predict risk for PTE1 (odds ratio [OR], 3.16 [0.99, 11.68]); subdural hematoma is another independent risk factor (OR, 4.13 [1.18, 39.33]). Differences in EA rates are apparent within 5 days following TBI. Our results suggest that increased EA prevalence identifies patients at increased risk for PTE1 , and that EAs acutely post-TBI can identify patients most likely to benefit from antiepileptogenesis drug trials. Ann Neurol 2018;83:858-862. |
| Databáze: | OpenAIRE |
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