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Background Ultrasonography (US) has recently been validated and used as an objective diagnostic tool for urate deposition also joint damage and was proposed as an outcome measure in gout [1–2]. Objectives Our aim was to investigate the relationship between clinical gout activity and load of US changes. Methods Sixty monosodium-urate-crystal-confirmed gout patients (52 men) and 36 healthy normouricemic controls were prospectively included in one centre. The relationship between clinical symptoms and US gout-related changes investigating 36 joints and 4 tendons (m. triceps and patellar) was evaluated using Spearman9s correlation. Results The total number of intraarticular T, periarticular T, total T, total DC, and total E found per patient on ultrasound ranged from 0–26, 0–4, 0–30, 0–29, and 0–18, accordingly.The number of acute attacks per year/per life had a significant positive correlation with the total number of intraarticular T (rs=0.518/0.652; p Conclusions Ultrasonographic gout -related changes strongly positively correlate between each other and with subjective also objective signs of disease activity, increasing with disease duration in gout. The size of tophi inside the first metatarsophalangeal joints could be representative of the total body urate load and could be chosen as an outcome measure for the longitudinal gout studies. References Neogi T, Jansen TLTA, Dalbeth N, Fransen J, Schumacher HR, Berendsen D, et al. 2015 Gout classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis. 2015 Sep 9; 74(10):1789–98. Ottaviani S, Gill G, Aubrun A, Palazzo E, Meyer O, Dieude P. Ultrasound in gout: a useful tool for following urate-lowering therapy. Jt Bone Spine 2015 Jan; 82(1):42–4. Disclosure of Interest None declared |
