Use of Mucin in Experimental Infections of Mice with Histoplasma capsulatum

Autor:	Charlotte C. Campbell, Samuel Saslaw
Rok vydání:	1950
Předmět:	Infectivity Stomach medicine.medical_treatment Mucin Virulence Biology medicine.disease biology.organism_classification Histoplasma capsulatum General Biochemistry Genetics and Molecular Biology Histoplasmosis Microbiology medicine.anatomical_structure Relative resistance Immunology medicine Saline
Zdroj:	Experimental Biology and Medicine. 73:469-472
ISSN:	1535-3699 1535-3702
DOI:	10.3181/00379727-73-17716
Popis:	Summary and ConclusionsH. capsulatum in the yeast phase when suspended in 5% hog gastric mucin and administered intraperitoneally into white mice caused a high percentage of fatal indections. Equivalent challenge doses of the organism suspended in saline rarely caused dleath. It was observed that by varying the number of organisms administered in mucin the mortality rate as well as the time interval between injection and death could be altered to suit the experimental requirements.Certain investigations on experimental histoplasmosis heretofore have been limited by the relative resistance of white mice to infection with H. capsulatum. “Virulence-enhancement” by mucin offers a means of extending the scope of such studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::07d0078610ecce766b6a64ce2786d910 https://doi.org/10.3181/00379727-73-17716 Zobrazit plný text záznamu