Tumor-to-tumor metastasis: esophageal carcinoma metastatic to an intracranial paraganglioma

Autor:	Moosa Khalil, Garnette Sutherland, Arthur W. Clark, William Hu, Jian-Qiang Lu
Rok vydání:	2009
Předmět:	Pathology medicine.medical_specialty business.industry Esophageal disease Cancer medicine.disease Metastasis Sella turcica medicine.anatomical_structure Blurred vision Paraganglioma Carcinoma Medicine Upper gastrointestinal bleeding medicine.symptom business
Zdroj:	Journal of Neurosurgery. 110:744-748
ISSN:	1933-0693 0022-3085
DOI:	10.3171/2008.9.jns08397
Popis:	Tumor-to-tumor metastasis (TTM) is a relatively rare but well-documented phenomenon. The authors report a unique case of esophageal carcinoma metastatic to an intracranial paraganglioma. A sellar and suprasellar tumor was found using MR imaging in an 81-year-old man who presented with a 3-week history of progressive headache and blurred vision. A subtotal excision of the tumor was achieved. Histopathological examination of the tumor disclosed a neoplasm with two distinct components: one showing the classic Zellballen pattern of a paraganglioma, the other exhibiting malignant features leading to the diagnosis of a poorly differentiated carcinoma metastatic to a sellar/suprasellar paraganglioma. The primary esophageal carcinoma was not uncovered until 2 months later, after the patient presented with upper gastrointestinal bleeding. The patient died 4 months after initial presentation. This case expands the spectrum of TTM, and emphasizes the importance of TTM in the practice of pathology.
Databáze:	OpenAIRE
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