Homologous desensitization of pancreatic beta cells to glucose response by polyunsaturated fatty acids
| Autor: | Emmanuel C. Opara, Warner M. Burch, Onye E. Akwari, Van S. Hubbard |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
chemistry.chemical_classification
endocrine system medicine.medical_specialty geography Nutrition and Dietetics geography.geographical_feature_category Arginine Linolenic acid Endocrinology Diabetes and Metabolism Linoleic acid Insulin medicine.medical_treatment Clinical Biochemistry Biology Islet Biochemistry chemistry.chemical_compound Endocrinology chemistry Internal medicine Homologous desensitization medicine Molecular Biology Pancreatic hormone Polyunsaturated fatty acid |
| Zdroj: | The Journal of Nutritional Biochemistry. 2:424-429 |
| ISSN: | 0955-2863 |
| DOI: | 10.1016/0955-2863(91)90111-h |
| Popis: | We have shown recently that a mixture of 10 m M linoleic acid (18:2,ω6) and 5 m M linoleic acid (18:3,ω3) enhanced insulin secretion by microdissected islets. In the present study, our aim was to examine the effect of a prestimulus with this mixture of 10 m M linoleic acid and 5 m M linoleic acid on glucose and arginine-stimulated insulin response, by perifused isolated islets. Insulin secretion by untreated (control) islets estimated as integrated area under the curve (AUC/ 20 mins) above basal during three pulses of 27.7 m M glucose separated by 20 min periods of basal (washout) perifusions were 2950 ± 585 pg, 5185 ± 1258 pg, and 2410 ± 921 pg, a greater response (P M arginine. These data suggest that (1) a mixture of 10 m M linoleic acid and 5 m M linolenic acid can desensitize isolated perifused islets to glucose but not arginine; and (2) glucose intolerance associated with lipemia may result, at least in part, from a direct effect on the islets of Langerhans. |
| Databáze: | OpenAIRE |
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