STUDY OF THE EFFECT OF PENTOXIFYLLINE IN HEPATIC ISCHEMIA-REPERFUSION INJURY IN ALBINO RATS
| Autor: | Somaia Mokbel, Karawan Abdel Rahman |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
business.industry
medicine.medical_treatment Pharmacology Liver transplantation medicine.disease Pentoxifylline Transplantation Pathogenesis Cytokine General Earth and Planetary Sciences Medicine Phosphodiesterase inhibitor business Reperfusion injury Saline General Environmental Science medicine.drug |
| Zdroj: | Mansoura Medical Journal. 35:147-163 |
| ISSN: | 2735-3990 |
| Popis: | Hepatic ischemia reperfusion injury (IRI) is a common pathological process of traumatic surgical disease in the liver, liver transplantation, shock and infection. Inflammatory mediators are implicated in the pathogenesis of IRI. Pentoxifylline (PTX) is a derivative of methylxanthines, acts as a phosphodiesterase inhibitor and thereby elevates the levels of cAMP. Interest in PTX has been recently reawakened because of its reported sup-pressive action on immune functions, particularly on cytokine production. It has been shown to be beneficial in organ transplantation. Pentoxifylline probably acts primarily by inhibiting tumor necrosis factor-a (TNF-a). We hypothesized that PTX treatment would attenuate hypoxic ischemic liver injury. Thirty-six male albino rats were used throughout this experiment. Animals were divided into 2 main groups; each comprised 18 rats (sham-operated & IRI groups). Group (1): sham-operated (exposed to anesthesia & laparotomy), this group is subdivided into 3 equal subgroups. Subgroup 1A: Sham- operated received daily intra-gastric saline, subgroup IB: sham-operated +PTX (8mg/kg/day) for 6 successive weeks before exposure to anesthesias laparotomy, subgroup 1C: as IB but received PTX (16mg/kg/day). Group (II): IRI group, divided into 3 equal subgroups, subgroup IIA,received intra-gastric saline for 6 weeks before the induction of IRI .subgroup MB, received 8mg/kg/ day PTX intra-gastrically for 6 weeks before induction of IRI, subgroup IIC |
| Databáze: | OpenAIRE |
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