Synthesis and properties of nanostructures based on lanthanum fluoride for photodynamic therapy of tumors of the cranial cavity and bone tissue
| Autor: | P. P. Gorbyk, V. A. Dubok, Yu. M. Shuba, Yu. L. Sobolevs'kyy, O. A. Bur'yanov, S. P. Turanska, A. L. Petranovska, O. I. Oranska, A. P. Kusyak, L. I. Kravchuk, D. I. Kravchuk, V. S. Chornyi |
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| Rok vydání: | 2021 |
| Předmět: |
Aqueous solution
Nanocomposite Materials science Coprecipitation Nanoparticle Surfaces and Interfaces Nanocrystalline material Surfaces Coatings and Films law.invention Colloid and Surface Chemistry Nanocrystal law Materials Chemistry Ceramics and Composites Physical and Theoretical Chemistry Crystallization Luminescence Nuclear chemistry |
| Zdroj: | Himia, Fizika ta Tehnologia Poverhni. 12:216-225 |
| ISSN: | 2079-1704 |
| Popis: | The aim of the work is the synthesis of nanostructures based on lanthanum fluoride, promising for use in photodynamic therapy of tumors in organs of cranial cavity and bone tissues; a study of their structural properties and luminescence spectra. Synthesis of LaF 3 :Tb 3+ was carried out by coprecipitation of components from aqueous and alcoholic (methanol) solution. As precursors were used: La(NO 3 ) 3 ×6H 2 O, TbCl 3 , NH 4 F. All reagents have qualification “chemically pure”. Distilled water and methanol were used as solvent. The synthesis of nanosized magnetite in the single-domain state was performed by the Elmore method. Synthesized nanodisperse samples are characterized by XRD analysis, DTGA, TEM. The magnetic properties and spectra of UV luminescence were also studied. It has been found that the XRD-patterns of LaF 3 :Tb 3+ samples synthesized in water and methanol do not differ fundamentally. Under the experimental conditions, the most perfect crystals of hexagonal syngony were formed during crystallization in an autoclave. Their average size was ~ 15 nm. In TEM images, the length of the crystals exceeds the width by 3–4 times. Crystals are prone to aggregation and the formation of chain structures. The UV luminescence spectrum of the synthesized nanodisperse samples in aqueous medium at the concentration of 0.5 mg/ml and excited by ultraviolet radiation is characteristic of the structure of LaF 3 :Tb 3+ . Ensembles of particles Fe 3 O 4 /LaF 3 :Tb 3+ NCs were synthesized. Transmission electron microscopy has shown that the shapes of particles of NCs and LaF 3 :Tb 3+ nanocrystals are fundamentally different. Particles of Fe 3 O 4 /LaF 3 :Tb 3+ NCs have a spherical shape, which is characteristic of structures of the core-shell type. X-ray diffraction patterns of NCs confirm this conclusion. The conditions for the synthesis of NCs did not significantly change the magnetic properties of their nuclei, single-domain Fe 3 O 4 nanoparticles (NPs). The luminescence spectrum of Fe 3 O 4 /LaF 3 :Tb 3+ NCs differs significantly from the spectrum of samples of nanodispersed LaF 3 :Tb 3+ both in intensity and in the structure of the bands. These spectral differences may be due to differences in structure, features of the nanocrystalline structure, the content of the LaF 3 :Tb 3+ scintillator and Tb 3+ ions in samples of LaF 3 :Tb 3+ nanocrystals and shells of Fe 3 O 4 /LaF 3 :Tb 3+ nanocomposites. Composites of dispersed 60S bioglass with nanodispersed crystalline LaF 3 :Tb 3+ in the dry state, and distilled water, showed the presence of luminescence upon excitation by UV radiation. The results of research show the prospects of the synthesized nanodispersed luminophors LaF 3 :Tb 3+ , for use as a source of luminescent radiation in optopharmacology and photodynamic therapy of tumors in organs of cranial cavity and bone tissues. Optimization of luminescent properties of the original nanodispersed luminophors, their compositions with bioactive glass, luminescent shells in the composition of magnetosensitive NCs, as well as the technology of manufacturing of these structures will significantly allow us to improve their performance characteristics. The results of the work indicate the prospects of the synthesized structures for further research under the conditions of excitation by high-permeability “soft” X-ray radiation for use in optopharmacology and photodynamic therapy of tumors in organs of cranial cavity and bone tissues. Optimization of properties of the original nanodispersed luminophors, their compositions with bioactive glass and magnetosensitive carriers Fe 3 O 4 will allow us to improve significantly their performance characteristics. |
| Databáze: | OpenAIRE |
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