Molecular Recognition of Medium-size Lactones by Enclathration of Cholic Acid

Autor:	Kazuki Sada, Nobutami Kasai, Kazuaki Kato, Kiichi Takemoto, Kazunori Nakano, Satoshi Sasaki, Mikiji Miyata, Kunio Miki, Kiyoshi Hirayama, Masashi Shigesato
Rok vydání:	2001
Předmět:	Steric effects chemistry.chemical_classification chemistry.chemical_compound Molecular recognition chemistry Stereochemistry Bilayer Cholic acid General Chemistry Crystal structure Enantiomer Lactone
Zdroj:	Supramolecular Chemistry. 13:35-44
ISSN:	1029-0478 1061-0278
DOI:	10.1080/10610270108034880
Popis:	Molecular recognitions of medium size lactones by enclathration of cholic acid (CA) are described. Size and location of the substituents on the lactone rings play an important role for enclathration. Lactones within the limited steric dimensions are included in CA, and larger or smaller ones are not included to give guest-free crystals of CA. Moreover, CA partially separates one enantiomer from racemic lactones by recystallization. X-ray crystallographic studies reveal that all included lactones form the β-trans type bilayer structure having a pentagonal void channel with a side pocket. The cross-sections illustrate that the lactone rings are incorporated in the center of the channel and that the substituents of the guests are fixed in the side pockets. The asymmetric channel enables CA to discriminate size and chirality of medium size lactones.
Databáze:	OpenAIRE
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