Association between the 5-HTTLPR Polymorphism of the Serotonin Transporter Gene with the Efficiency and Tolerability of Selective Serotonin Reuptake Inhibitors
| Autor: | A. V. Matveev, S. V. Orlov, T. I. Avdeeva, Yu. G. Tikhonova, N. G. Dashkova, M. A. Kinkulkina, A. A. Ragimov, O. E. Kuznetsov, T. A. Izyumina, N. N. Ivanets |
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| Rok vydání: | 2017 |
| Předmět: |
biology
business.industry General Neuroscience Serotonin reuptake inhibitor Pharmacology Serotonin reuptake 030227 psychiatry 03 medical and health sciences 0302 clinical medicine Antidepressant therapy 5 httlpr polymorphism Tolerability mental disorders Genotype biology.protein Medicine business Gene 030217 neurology & neurosurgery Serotonin transporter |
| Zdroj: | Neuroscience and Behavioral Physiology. 47:386-392 |
| ISSN: | 1573-899X 0097-0549 |
| DOI: | 10.1007/s11055-017-0411-5 |
| Popis: | Objective. To identify the association between the 5-HTTLPR polymorphism of the serotonin transporter gene with the efficacy and tolerability of antidepressant therapy with a selective serotonin reuptake inhibitor (SSRI). Materials and methods. A complex clinical-psychopathological and genetic study of 38 patients with depression during SSRI treatment was conducted. Results and conclusions. Statistical associations between the 5-HTTLPR polymorphism and the levels of remission and tolerability were identified: carriers of the SS genotype rarely achieved remission and developed more severe side effects. |
| Databáze: | OpenAIRE |
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