Preventive and Therapeutic Effects of α1-Acid Glycoprotein in Mice Infected with B. anthracis
| Autor: | V N Stepanshina, I G Shemyakin, V A Aleshkin, S S Afanas'ev, G V Shmarina, A L Pukhalsky |
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| Rok vydání: | 2005 |
| Předmět: |
chemistry.chemical_classification
biology Inoculation Therapeutic effect Lethal dose General Medicine Pharmacology biology.organism_classification Virology General Biochemistry Genetics and Molecular Biology Bacillus anthracis chemistry Concanavalin A biology.protein Tumor necrosis factor alpha Glycoprotein Survival rate |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 140:439-444 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | We studied the effects of alpha1-acid glycoprotein preparations on the survival rate of BALB/c mice infected with the lethal dose of B. anthracis STI-1. Apart from native alpha1-acid glycoprotein from donor blood, we studied 3 glycoforms differing in the affinity for concanavalin A and structure of carbohydrate chains. The protective effect of alpha1-acid glycoprotein preparations did not depend on its dose and was observed 3 months after treatment (0.3 mg per mouse). The protective effect was revealed in mice receiving alpha1-acid glycoprotein preparations 2 h before infection and 24 h after inoculation of the bacterial culture. In the latter case the survival rate of animals was much higher compared to that observed in preventive administration of alpha1-acid glycoprotein. The protective effect practically did not depend on the time of treatment with glycoforms. Pretreatment with alpha1-acid glycoprotein preparations significantly decreased plasma interferon-gamma concentration. Administration of the test preparations 24 h after infection decreased the concentration of tumor necrosis factor-alpha. |
| Databáze: | OpenAIRE |
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