White matter disruption as a cause or consequence of schizophrenia: A Mendelian randomization study

Autor:	Doug Speed, Karl J. Friston, Søren Dinesen Østergaard, Maria Speed, Oskar Hougaard Jefsen
Rok vydání:	2021
Předmět:	Functional integration (neurobiology) business.industry medicine.disease White matter medicine.anatomical_structure Neuroimaging Schizophrenia Mendelian randomization Fractional anisotropy Medicine In patient Synaptopathy business Neuroscience
DOI:	10.1101/2021.08.23.21262451
Popis:	Brief abstractSchizophrenia is hypothesized to be caused by impaired functional integration in the brain, and this could hypothetically be caused by white matter disruptions, synaptic dysfunction, or both. Neuroimaging studies consistently show reduced fractional anisotropy, a measure of white matter integrity, in patients with schizophrenia. Using Mendelian randomization, we show that these white matter changes are likely to be the consequence of a primary synaptopathy in schizophrenia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::079484cfb9c91ac9c616a313d0c5d12e https://doi.org/10.1101/2021.08.23.21262451 Zobrazit plný text záznamu