Biological Activity of Thiazole Derivatives on Some Pathogenic Microorganisms

Autor:	Shayma M. Ahmad, Shaukat Saeed, Firas Hassan
Rok vydání:	2011
Předmět:	biology Microorganism Geotrichum Trichophyton rubrum biology.organism_classification medicine.disease_cause Microbiology Incubation period chemistry.chemical_compound chemistry Staphylococcus aureus medicine skin and connective tissue diseases Thiazole Escherichia coli Bacteria
Zdroj:	Journal of Al-Nahrain University Science. 14:1-6
ISSN:	2519-0881 1814-5922
DOI:	10.22401/jnus.14.1.01
Popis:	The thiazole derivatives were prepared by the reaction of benzaldehyde derivatives with (2-thiooxamide-5-(p-bromobenzene)-1,3-thiazole) that was readily prepared by heating dithiooxamide with 4-bromophenacylbromide. Within invitro study the the effect of the prepared compounds on the growth of two types of fungi geotrichum cadidum and Trichophyton rubrum and the bacteria Escherichia coli, pseudomonas aeruginosa, Staphylococcus aureus, and Klebsiella pneumoniae was evaluated. Incubation time and concentration were studied to find the optimal conditions for the activity. Compound II with the concentration 20 mg/ml found to be the most active compound toward geotrichum and Trichophyton rubrum. Statistical analysis of the values of colonial diameter shows low percentage error for the studied fungi with regard to incubation time.
Databáze:	OpenAIRE
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