Tetrahydrothienopyridine derivatives as novel GPIIb/IIIa antagonists

Autor:	Kiyoaki Katano, Kazue Sasaki, Takashi Tsuruoka, Masaro Shimizu, Shokichi Ohuchi, Yasuko Isomura, Mami Kawaguchi, Eiki Shitara, Tomoaki Miura
Rok vydání:	1996
Předmět:	Chemistry Gpiib iiia antagonist Stereochemistry Organic Chemistry Clinical Biochemistry Antagonist Pharmaceutical Science Biochemistry Combinatorial chemistry Drug Discovery Molecular Medicine Moiety Molecular Biology circulatory and respiratory physiology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 6:2601-2606
ISSN:	0960-894X
DOI:	10.1016/0960-894x(96)00476-3
Popis:	The tetrahydrothienopyridine derivatives were derived from aminomethylcyclohexylcarboxylic acid as a lead moiety. Evaluation of the antiplatelet activity and receptor binding assay revealed that compound 1(ME3277) was a novel and potent non-peptide and non-amidinophenyl GPIIb/IIIa antagonist.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0789bb53e6a25e5a5cc30cedaadec4ac https://doi.org/10.1016/0960-894x(96)00476-3 Zobrazit plný text záznamu Full Text from ScienceDirect