IV Magnesium Sulfate in the Treatment of Acute Severe Asthma
| Autor: | E. John Gallagher, Jeffrey W Runge, Katherine Freeman, Bruce Levin, Steven M. Scharf, William Chiang, Harold H Osborn, Noel Mancherje, Theodore J. Gaeta, James A. Feldman, Robert Silverman |
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| Rok vydání: | 2002 |
| Předmět: |
Pulmonary and Respiratory Medicine
Spirometry medicine.medical_specialty medicine.diagnostic_test business.industry Respiratory disease Emergency department Critical Care and Intensive Care Medicine medicine.disease respiratory tract diseases law.invention Pulmonary function testing Surgery Clinical trial Randomized controlled trial law Acute severe asthma Internal medicine Medicine Cardiology and Cardiovascular Medicine business Asthma |
| Zdroj: | Chest. 122:489-497 |
| ISSN: | 0012-3692 |
| DOI: | 10.1378/chest.122.2.489 |
| Popis: | Background: Studies of IV magnesium sulfate as a treatment for acute asthma have had mixed results, with some data suggesting a benefit for acute severe asthma, but not for mild-to-moderate asthma. In a multicenter cohort, this study tests the hypothesis that administration of magnesium sulfate improves pulmonary function in patients with acute severe asthma. Design: Placebo-controlled, double-blind, randomized clinical trial. Setting: Emergency departments (EDs) of eight hospitals. Patients: Patients aged 18 to 60 years presenting with acute asthma and FEV1 25% predicted, magnesium administration was not beneficial; the final FEV1 was 51.1% predicted in the magnesiumtreated group and 53.9% predicted in the placebo-treated group (mean difference, 2.9%, 95% CI, 9.4 to 3.7; p not significant). Overall, the use of magnesium sulfate did not improve hospital admission rates. Conclusion: Administration o f2go f IVmagnesium sulfate improves pulmonary function when used as an adjunct to standard therapy in patients with very severe, acute asthma. (CHEST 2002; 122:489–497) |
| Databáze: | OpenAIRE |
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