Using Bayesian proof-of-concept criteria to design randomized phase II oncology trials stratified by biomarker status

Autor:	K. V. Appanna, V. Jehl, Y. Wang, Emmanuel Zuber, Y. Zhang, A. racine-Poon, B. Neuenschwander
Rok vydání:	2011
Předmět:	Oncology Cancer Research medicine.medical_specialty business.industry medicine.medical_treatment Bayesian probability Targeted therapy Clinical trial Proof of concept Internal medicine medicine Biomarker (medicine) Stage (cooking) business
Zdroj:	Journal of Clinical Oncology. 29:e21150-e21150
ISSN:	1527-7755 0732-183X
DOI:	10.1200/jco.2011.29.15_suppl.e21150
Popis:	e21150 Background: In the early stage development of a targeted therapy, assumed to be more effective in a specific subpopulation, it is very challenging to decide whether clinical trials should be...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::077c05c3838fc207a756d9123347f5d8 https://doi.org/10.1200/jco.2011.29.15_suppl.e21150 Zobrazit plný text záznamu