Ru(II)-catalyzed ortho-amidation and decarboxylation of aromatic acids: a versatile route to meta-substituted N-aryl benzamides

Autor:	Xue-Fen Dong, Xian-Ying Shi, Chao-Jun Li, Juan Fan, Ke-Yan Liu, Junfa Wei
Rok vydání:	2015
Předmět:	chemistry.chemical_compound Chemistry Decarboxylation Aryl Organic chemistry Homogeneous catalysis General Chemistry Carboxylate Combinatorial chemistry Catalysis
Zdroj:	Science China Chemistry. 58:1286-1291
ISSN:	1869-1870 1674-7291
Popis:	Carboxylate as a promising and valuable directing group has attracted a great deal of attention. However, employing it as a traceless direction group has rarely been reported. We developed the ruthenium-catalyzed amidation of substituted benzoic acids with isocyanates via directed C-H functionalization followed by decarboxylation to afford the corresponding meta- substituted N -aryl benzamides, in which the carboxylate serves as a unique, removable directing group. Notably, this protocol can provide an efficient alternative to access meta -substituted N -aryl benzamides, which are much more difficult to prepare than ortho -substituted analogues.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::077874e2e23bc20c89ec5db19ac142eb https://doi.org/10.1007/s11426-015-5364-3 Zobrazit plný text záznamu Full text from SpringerLink