Fibrodysplasia Ossificans Progressiva: Oral Ascorbate and Intravenous Bisphosphonate during Flare-Ups
| Autor: | Ligia Maria Leme, Erica Naomi Naka, Petr Melnikov, Durval Batista Palhares |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Disodium clodronate business.industry medicine.medical_treatment Pain onset Bisphosphonate medicine.disease Ascorbic acid Gastroenterology Pathophysiology Endocrinology Rheumatology Fibrodysplasia ossificans progressiva Internal medicine medicine Severe pain Flare up business |
| Zdroj: | Journal of Musculoskeletal Pain. 18:270-276 |
| ISSN: | 1540-7012 1058-2452 |
| DOI: | 10.3109/10582452.2010.501300 |
| Popis: | Background: The paper reports on two cases of fibrodysplasia ossificans progressiva, a genetically determined condition with no pathogenetic treatment. The pathophysiology of the disease is known partially only. Clinically, it is characterized by flare-ups accompanied by severe pain and ectopic ossifications.Findings: The patients’ general condition improved when they were continuously treated with ascorbic acid and periodically received disodium clodronate. The latter reduced the duration and intensity of flare-ups. Early administration of intravenous disodium clodronate at pain onset can prevent flare-ups.Conclusion: Ascorbic acid diminishes pain and makes flare-ups less frequent. The study provides evidence of a possible synergism of ascorbic acid and disodium clodronate during the long-term treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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