Phosphonoselenoic acid esters from the reaction between phosphoroselenoyl chlorides and Grignard reagents: synthetic and stereochemical aspects
| Autor: | Mao Minoura, Toshiaki Murai, Kazuma Kuwabara, Yuuki Maekawa, Yuuki Hirai |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Substitution reaction
Recrystallization (geology) 010405 organic chemistry Chemistry General Chemical Engineering Absolute configuration Diastereomer General Chemistry 010402 general chemistry 01 natural sciences Chloride 0104 chemical sciences Column chromatography Phosphorus atom Reagent medicine Organic chemistry medicine.drug |
| Zdroj: | RSC Advances. 6:15180-15183 |
| ISSN: | 2046-2069 |
| DOI: | 10.1039/c6ra00318d |
| Popis: | Substitution reactions between a phosphoroselenoyl chloride and Grignard reagents proceeded smoothly at the phosphorus atom to furnish phosphonoselenoic acid esters. The resulting mixture of diastereoisomers could be readily distinguished on the basis of 31P NMR, and separated by recrystallization or column chromatography to afford diastereoisomerically enriched products. For one of these diastereoisomers, the absolute configuration was determined by carrying out a single-crystal X-ray diffraction analysis. |
| Databáze: | OpenAIRE |
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