A microfabricated neural probe with porous si-parylene hybrid structure to enable a reliable brain-machine interface
| Autor: | Tao Sun, Gavin S. Dawe, Beibei Han, Wei Mong Tsang, Alex Yuandong Gu, Srinivas Merugu, Woo-Tae Park, Ning Xue, Yunxiao Liu |
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| Rok vydání: | 2016 |
| Předmět: |
Fabrication
Materials science Interface (computing) 0206 medical engineering technology industry and agriculture 02 engineering and technology 021001 nanoscience & nanotechnology Porous silicon 020601 biomedical engineering chemistry.chemical_compound Parylene chemistry Drug reservoir 0210 nano-technology Porosity Cmos compatible Brain–computer interface Biomedical engineering |
| Zdroj: | 2016 IEEE 29th International Conference on Micro Electro Mechanical Systems (MEMS). |
| DOI: | 10.1109/memsys.2016.7421581 |
| Popis: | To establish a reliable brain-machine interface (BMI), we report for the first time, a multifunctional porous silicon (PSi)-parylene neural probe using a CMOS compatible fabrication process. The biodegradable PSi shank serves as a mechanical stiffener for insertion process, then dissolves to leave only the polymeric structure to reduce stiffness mismatch between implant and cortical tissue, thus attenuates tissue responses. Moreover, its porous structure can serve as drug reservoir. The healing of the insertion trauma can be enhanced by continuously releasing pre-loaded drugs with the PSi degradation. Hence, the neural probe enables a more reliable BMI. |
| Databáze: | OpenAIRE |
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