| Autor: |
Jonathan R. Gaillard, Zeina Shreif, Junghyo Jo, Samuel W. Cushman, Matilde Arroyo, Vipul Periwal |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
The Mechanobiology of Obesity and Related Diseases ISBN: 9783319093352 |
| DOI: |
10.1007/8415_2013_170 |
| Popis: |
Adipose tissue is the main organ for long term storage of energy in the body. Adipose cells store excess energy by enlarging and/or increasing in number, while they provide energy by releasing fat and shrinking as needed. The regulation of energy storage capacity is not a simple problem considering the uncertainty of following food intakes and physical activities. In this Chapter, we introduce the inference of adipose tissue dynamics from adipose cell-size distributions using mathematical modeling and Bayesian inference. We examine recruitment of new adipose cells, growth/shrinkage and death of existing cells under positive/negative energy balance. A comprehensive understanding of adipose tissue dynamics can provide new insights into metabolic disorders such as obesity and diabetes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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