Iridium- and Rhodium-Catalyzed [2+2+2] Cycloadditions of Diynes with Maleimide: A New Synthetic Route to Highly Substituted Phthalimides

Autor:	Jacques Einhorn, Leonardo X. Alvarez, Bernard Bessieres
Rok vydání:	2008
Předmět:	Phthalimides chemistry.chemical_compound chemistry Organic Chemistry chemistry.chemical_element Iridium Medicinal chemistry Maleimide Cycloaddition Rhodium Catalysis
Zdroj:	Synlett. 2008:1376-1380
ISSN:	1437-2096 0936-5214
DOI:	10.1055/s-2008-1072746
Popis:	The [2+2+2] cycloaddition of maleimide with α,ω-diynes in the presence of [IrCl(cod)] 2 or [RhCl(cod)] 2 and DPPE gives cyclohexadiene derivatives which are readily aromatized with DDQ or MnO 2 . This two-step procedure gives access to highly substituted phthalimides in good yields.
Databáze:	OpenAIRE
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