Preliminary assessment of radioiodinated fenoterol and reproterol as potential scintigraphic agents for lung imaging
| Autor: | Mohamed M. Swidan, M. T. El-Kolaly, M. A. Motaleb, Tamer M. Sakr, A. Abd El-Bary |
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| Rok vydání: | 2014 |
| Předmět: |
Biodistribution
Lung Chemistry business.industry Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health Reproterol respiratory system Pharmacology Pollution In vitro Analytical Chemistry medicine.anatomical_structure Nuclear Energy and Engineering In vivo Lung imaging medicine Radiology Nuclear Medicine and imaging Receptor Nuclear medicine business Spectroscopy Fenoterol medicine.drug |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry. 303:531-539 |
| ISSN: | 1588-2780 0236-5731 |
| Popis: | Radioiodinated fenoterol and reproterol were prepared by electrophilic radioiodination reaction using chloramin-T as oxidizing agent with radiochemical yields of 97.7 ± 0.7 and 95.2 ± 0.3 %, respectively, and in vitro stability up to 72 h. Biodistribution study performed in male Albino Swiss mice showed maximum radioactivity accumulation in lungs tissue to the extent of 52 ± 1.03 and 50.6 ± 1.2 % ID/g at 15 and 30 min post injection (p.i.) for radioiodinated fenoterol and reproterol, respectively, with low accumulation in heart and blood. The clearance pathway of both iodo-compounds was through renal and hepatobiliary routes. The selectivity of iodo-compounds to lung was examined by in vivo receptor blocking study. Radioiodinated fenoterol and reproterol are not a blood products and so they are more safer than the currently available 99mTc-MAA, and their lungs uptake is higher than that of the recently discovered 125/123I-IPMPD, 99mTc(CO)5I, 99mTc-DHPM and 125/123I-paroxetine. So, radioiodinated fenoterol and reproterol could be introduced as a new compromising radiopharmaceuticals for lung perfusion scintigraphy more safe than the currently available 99mTc-MAA and more potential than the recently discovered 125/123I-IPMPD, 99mTc(CO)5I, 99mTc-DHPM and 125/123I-paroxetine. |
| Databáze: | OpenAIRE |
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