Successful Treatment of Earlobe Keloids with Imiquimod after Tangential Shave Excision
| Autor: | Mitchell E. Stashower |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Chemotherapy business.industry medicine.medical_treatment Cytokine profile Imiquimod Dermatology General Medicine Shave Excision Debulking Asymptomatic Surgery medicine.anatomical_structure medicine medicine.symptom Topical imiquimod skin and connective tissue diseases business Earlobe medicine.drug |
| Zdroj: | Dermatologic Surgery. 32:380-386 |
| ISSN: | 1076-0512 |
| DOI: | 10.1111/j.1524-4725.2006.32077.x |
| Popis: | BACKGROUND The treatment of earlobe keloids has historically been suboptimal; characterized by discomfort, poor response, and high rates of recurrence. Keloids are characterized by increased fibroblast activity in the setting of an altered cytokine profile. OBJECTIVE To investigate whether topical imiquimod 5% cream applied postoperatively after tangential excision can prevent recurrence of earlobe keloids. METHODS AND MATERIALS Four patients with a total of eight large pedunculated earlobe keloids (five of which were recurrent lesions) were treated with debulking by tangential shave excision followed by daily application of imiquimod 5% cream for 6 weeks. RESULTS At 6 and 12 months post-treatment there was an excellent cosmetic result and no evidence of recurrence in any of the lesions. Patients with keloids that were itchy and painful were completely asymptomatic at the conclusion of the study. CONCLUSION In this pilot study, imiquimod 5% cream following tangential shave excision was efficacious for the treatment of earlobe keloids. Further study is warranted to confirm the utility of imiquimod 5% cream in the treatment of earlobe keloids, as illustrated herein. |
| Databáze: | OpenAIRE |
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