64 PERICARDIAL EFFUSION IN CONGENITAL HYPOTHYROID INFANTS: AN AETIOLOGICAL CORRELATION
| Autor: | Angelo Bollati, G F Rondanini, Giovanna De Panizza, Ambra Pampalone, Salvatore Corallo, Giuseppe Chiumello, M R Mutinelli |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Newborn screening
medicine.medical_specialty Pediatrics medicine.diagnostic_test business.industry Thyroid medicine.disease Scintigraphy Pericardial effusion Congenital hypothyroidism medicine.anatomical_structure TRH stimulation test Internal medicine Pediatrics Perinatology and Child Health medicine Etiology Cardiology Thyroid function business |
| Zdroj: | Pediatric Research. 19:614-614 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-198506000-00084 |
| Popis: | Ten children positive at the newborn screening program for congenital hypothyroidism were studied. Confirming diagnosis was made in 8/10 infants,while 2/10 were false positive. Moreover we have considered in the study a patient clinically diagnosed at 19 months (he did not undergo the screening program),in which was demonstrated an ectopic gland.A complete thyroid function evaluation (FT3,FT4,T3,T4,TBG,TRH test),scintigraphy (TC99),echocardiography (B-mode)were carried out in all the babies (scintigraphy was not performed in the 2 false positive children). Pericardial effusion was demonstrated in 4/9 patients (44%); complete resolution occurred after a variable period of L-T4 therapy (15 days to 5 months).None of the patients showed clinical symptoms nor electrocardiographic signs of cardiac failure. Based on the aetiology the distribution was the following: Pericardial effusion correlates with the aetiology and probably depends on the severity of the thyroid failure. The high incidence of this finding in congenital hypothyroid children at diagnosis suggests the need for an initial L-T4 dosage lower than the dosage usually recommended (in our patients 5 to 7 mcg/kg/day allowed the normalization of FT3 and FT4 levels within 15 days of treatment) to avoid cardiac disturbances. |
| Databáze: | OpenAIRE |
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