| Popis: |
Nanoscale materials are routinely developed, characterized, and evaluated as diagnostic and therapeutic agents for disease treatment in humans. However, the size and composition of many such agents result in poor clearance profiles within biological tissues, thereby posing profound challenges to translational clinical applications. Herein, we present a hyperspectral imaging technique capable of quantifying plasmonic nanoparticle biodistribution with single particle limit of detection and microanatomical detail. Using this method, we find that, although intravenous administration of plasmonic nanoparticles remains largely infeasible from a biodistribution perspective, alternate routes relevant to treatment of oral and gastrointestinal diseases are within translational reach. |
