UK-73,093: A non-peptide neurotensin receptor antagonist
| Autor: | Frederic J. Vinick, Jacqueline N. Crawley, R. Michael Snider, Kelly P. Longo, Ralph E. Davidson, Ece Genc-Sehitoglu, Kirsti Laitinen, Dennis A. Pereira |
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| Rok vydání: | 1992 |
| Předmět: |
Chemistry
digestive oral and skin physiology Organic Chemistry Clinical Biochemistry Antagonist Pharmaceutical Science Pharmacology complex mixtures Biochemistry Non peptide In vitro chemistry.chemical_compound In vivo Drug Discovery Enzyme-linked receptor Molecular Medicine Neurotensin receptor Receptor Molecular Biology hormones hormone substitutes and hormone antagonists Neurotensin |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 2:1535-1540 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(00)80423-0 |
| Popis: | UK-73,093 was identified in a screening program as a compound able to displace [ 3 H]-neurotensin from its bovine brain receptor. We describe the discovery of this compound, species differences in receptor affinity and its characterization as a functional neurotensin antogonist in vitro and in vivo . |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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